Radiation therapy is commonly used after surgery for various types of cancer, including breast cancer. Despite protection and safety measures, radiation therapy leads to a limited exposure of the lungs and heart to radiation, raising the risk of severe cardiac and pulmonary diseases and secondary tumours.

The EU-funded TETRIS project aims to develop and test personalised risk scores to better predict and mitigate side effects caused by radiation therapy. Researchers will calibrate prediction models, taking into account patient-specific data from imaging, genetics and transcriptomics. To further improve radioprotection strategies, TETRIS will explore the use of digital twins or virtual replicas of individual patients for enhanced risk assessment and tailored follow-up care.