Fondazione IRCCS Istituto Nazionale dei Tumori (INT) is a leading national and international cancer treatment and research centre.
The Institute addresses clinical challenges across all cancer stages, focusing on: prevention and prediction, diagnosis and treatment (surgery, medicine,radiotherapy), rehabilitation and psychological support, pain management and palliative care. Its mission combines delivering current treatments with pioneering new ones through preclinical, clinical, and data science research, rapid translation of discoveries into improved patient care and quality of life.
Tiziana Rancati, senior physics researcher engaged in translational research in the field of outcome modelling after oncological treatments, is the head of the CMON Lab (Computational Modelling for Oncology Needs) which includes Physicists, Engineers, Mathematicians, Statisticians, and Research Assistants working in Oncology studies for modelling clinical outcomes. The main research focus is radiobiology, with a strong interest in quantitative imaging and biological characteristics describing mechanisms involved in treatment reactions. Proof of mechanisms is also tested through In-Silico simulations.
The INT project team includes Dr. Maria Carmen De Santis, Carlotta Giandini, and Maria Grazia Carnevale, radiation oncologists from the Diagnostic Imaging and Radiotherapy, Radiation Oncology Unit; Alessandro Cicchetti, Luca Possenti, Eliana Gioscio, Jacopo Jacovacci, Benedetta Dionisi Ferrera, Francesco Pisani, as multidisciplinary research team, and is supported by Clara Marrone, Daniela Bavuso, and Tania Sanna as coordination team from the Data Science Unit, CMON Lab.
Under Tiziana Rancati’s leadership as Project Investigator, INT is responsible for Work Package 1 – Coordination and Project Management, which ensures the timely and high-quality delivery of project results through technical, organisational, and financial coordination. WP1 guarantees that project agreements and objectives are correctly implemented, while also overseeing the management of data and knowledge generated throughout the project.
INT also leads Work Package 9 – Prospective Collection, which establishes a standardised prospective dataset of breast cancer patients receiving radiotherapy after conservative surgery in clinical centres across the TETRIS Consortium. The protocol for the TETRIS prospective observational study.reflects the project’s core vision: integrating biological, clinical, imaging, and behavioral data to improve and enhance digital twins for breast cancer radiotherapy. This new data will support the development of detailed digital twins for radiation safety applications.
In addition, INT coordinates Work Package 10 – Dissemination and Exploitation, which focuses on communicating and promoting project activities and outcomes through targeted dissemination, exploitation, and communication actions addressed to relevant stakeholders : scientific/clinical, industry, regulatory/policy, patient/civil society, and the general public. It also creates synergies with ongoing initiatives and related projects.
