After the success of the first TETRIS Educational Webinar on Dose-response modelling for normal tissues and model selection strategy, on February 27, 2026, Claudio Fiorino, Medical Physics at the San Raffaele Institute and Vita Salute University, in Milan, delivered the 2nd TETRIS Education Webinar on Methods for assessing quantitative imaging biomarkers (qIB) in breast cancer RT within the TETRIS project.
The presentation covered the rationale for using medical images to objectively score radiation-related toxicity, and introduced the full spectrum of radiomic features, from simple geometry and intensity-based descriptors to higher-order texture features. A key focus was placed on the persistent challenges of clinical usability, reproducibility, and standardisation of qIB, highlighting the importance of robust methodology, careful validation, and the use of explainable, parsimonious models to avoid overfitting.
Within the TETRIS project framework, he presented the ongoing work of WP3, which leverages planning CT images to extract patient-specific risk factors, particularly through CT densitometry of the lung and heart, without requiring any additional imaging beyond what is routinely available. Promising analyses on the OSR cohort (1,172 patients) are underway to link lung and cardiac densitometric features, including coronary artery calcification scores, to late respiratory and cardiac events after breast RT.
The seminar also addressed the complexity of multi-centric analyses, tackling inter-institute variability in auto-segmentation and HU calibration, and outlined future directions toward sub-structure segmentation and voxel-wise spatial approaches to further refine personalised risk modelling.
Please find Claudio Fiorino’s presentation here.
The webinar “Methods for assessing quantitative imaging biomarkers (qIB) in breast cancer RT within the TETRIS project” has been recorded and is available on TETRIS YouTube channel here. Link to Webinar here.
The next webinar, titled “Transcriptomic Risk Score Development for Risk Modelling: The TETRIS WP5 Framework.”, will take place on 26 March and will be delivered by Ana Vega and Miguel E. Aguado-Barrera from Fundación Pública Gallega de Medicina Genómica(FPGMX).
With the TETRIS Educational Series, we aim to provide high-quality training opportunities, stimulate dialogue among experts, and engage a wider audience interested in radiation safety and innovation in cancer care.
